Author

Ramakrishna P. Alur

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian P. BrooksiD· 2 shared Tiziana Cogliati· 2 shared Vijay K. KalaskariD· 2 shared A. ThompsoniD· 1 shared Ala MoshiriiD· 1 shared Andrea MinellaiD· 1 shared Andrew John LoteryiD· 1 shared Antonio Jacobo LopeziD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPharmacology & Toxicology

Brian P. BrooksORCID

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2 papers

Recent·Most cited

Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of Hypopigmentation.

Monika B. Dolinska, Yuhong Wang, Nathan P. Coussens, Vijay K. Kalaskar, Zuhal Eraslan, Samuel J. Grondin, Joseph Bonica, Sarah Toay, Matthew D. Hall, Min Shen, Matthew B. Boxer, Qiuying Chen, Steven S. Gross, Nabeel Attarwala, Yingyos Jittayasothorn, , Brian P. Brooks

The paper identifies ampyrone as a direct activator of human tyrosinase, showing increased catalytic activity and melanin synthesis in melanocytes and skin cultures, suggesting potential therapeutic use for hypopigmentation disorders.

bioRxiv · Oct 13, 2025 · PreprintPharmacology & Toxicology

Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure Closure

Elangovan Boobalan, A. Thompson, Ramakrishna P. Alur, David M. McGaughey, Lijin Dong, Grace C. Shih, Emile R. Vieta-Ferrer, Ighovie F. Onojafe, Vijay K. Kalaskar, Gavin Arno, Andrew John Lotery, Bin Guan, Chelsea Bender, Omar Memon, Lauren Brinster, , Brian P. Brooks

The paper shows that Zfp503 is essential for RPE differentiation and optic fissure closure, with loss of function leading to uveal coloboma and altered gene expression in developing mouse eyes.

Investigative Ophthalmology & Visual Science · Nov 3, 2022Peer-reviewedDevelopmental Biology