Julie C. Matte

The paper introduces TGlow, a high-content imaging platform for single-cell phenotyping of human lymphocytes, revealing distinct morphological states and drug responses.

This study investigates the effects of the PLCγ2 S707Y hypermorphic variant on human microglia, showing increased enzymatic activity but reduced phagocytosis and cytokine production, and suggests therapeutic strategies should mimic the beneficial effects of the P522R variant.

The paper maps eQTLs during T cell activation and identifies immune disease risk variants that regulate gene expression dynamics, showing colocalization with disease-associated genes.