Author

Anna Lorenc

Wellcome Sanger InstituteORCID 0000-0002-1406-7607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Blagoje SoskiciD· 2 shared Gosia TrynkaiD· 2 shared Nikolina Nakić· 2 shared Ziying KeiD· 2 shared Annalisa BunielloiD· 1 shared Daniel ConsidineiD· 1 shared David F. ToughiD· 1 shared David OchoaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Blagoje SoskicORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Genetic dose-response modelling predicts drug mechanisms, dosing, and adverse events

Luca Stefanucci, Daniel Considine, Ziying Ke, Joel Hellewell, Olivier B. Bakker, Marta Perez‐Alcantara, Blagoje Soskic, Krista Freimann, Michael C. Turchin, Emily Rose Holzinger, Joshua Chiou, Nikolina Nakić, Halit Ongen, Anna Lorenc, Maya Ghoussaini, , Gosia Trynka

VIDRA models genetic dose-response relationships to predict drug mechanisms, therapeutic potential, and adverse events using phenotypically associated variants.

medRxiv · Jul 6, 2026 · PreprintGenetic & Genomic Medicine

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Kirsty Ambridge, Ziying Ke, Julie C. Matte, Lara Bossini‐Castillo, Joanna Kaplanis, Lucia Ramirez-Navarro, Anna Lorenc, Nikolina Nakić, Jorge Esparza-Gordillo, Wendy C. Rowan, David R. Willé, David F. Tough, , Gosia Trynka

The paper maps eQTLs during T cell activation and identifies immune disease risk variants that regulate gene expression dynamics, showing colocalization with disease-associated genes.

Nature Genetics · May 26, 2022Peer-reviewedGenomics