Author

Deborah J. Smyth

Wellcome Sanger InstituteORCID 0000-0002-6330-2669Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:scRNA-seq· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Blagoje SoskiciD· 3 shared Eddie Cano-GameziD· 3 shared Gosia TrynkaiD· 3 shared Lara Bossini‐CastilloiD· 3 shared David F. ToughiD· 2 shared David R. WilléiD· 2 shared Jorge Esparza-Gordillo· 2 shared Nikolina Nakić· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Blagoje SoskicORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Kirsty Ambridge, Ziying Ke, Julie C. Matte, Lara Bossini‐Castillo, Joanna Kaplanis, Lucia Ramirez-Navarro, Anna Lorenc, Nikolina Nakić, Jorge Esparza-Gordillo, Wendy C. Rowan, David R. Willé, David F. Tough, , Gosia Trynka

The paper maps eQTLs during T cell activation and identifies immune disease risk variants that regulate gene expression dynamics, showing colocalization with disease-associated genes.

Nature Genetics · May 26, 2022Peer-reviewedGenomics

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Wendy C. Rowan, Nikolina Nakić, Jorge Esparza-Gordillo, Lara Bossini‐Castillo, David F. Tough, Christopher G. C. Larminie, Paola G. Bronson, David R. Willé, Gosia Trynka

The paper identifies T cell states associated with immune disease variants by analyzing chromatin activity across different activation states.

Nature Genetics · Sep 23, 2019Peer-reviewedGenetics

Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets

Lara Bossini‐Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, Kaur Alasoo, Alice Mann, Kousik Kundu, Nicole Soranzo, Ian Dunham, , Gosia Trynka

The paper identifies immune disease variants affecting Treg gene expression and highlights potential drug targets by linking GWAS signals with Treg QTLs.

bioRxiv · May 31, 2019 · PreprintGenetics