Induction of telomerase in p21-positive cells counteracts capillaries rarefaction in aging mice lung
Larissa Lipskaia, Marielle Breau, Christelle Cayrou, Dmitri Churikov, Laura Braud, Charles Fouillade, Sandra Curras-Alonso, Serge Bauwens, Frédéric Jourquin, Frédéric FIORE, Rémy Castellano, Emmanuelle Josselin, Carlota Sánchez-Ferrer, Giovanna Giovinazzo, Éric Gilson, , Vincent Géli
The paper shows that inducing telomerase in p21-positive cells in aging mice lungs reduces capillary rarefaction and improves lung function by promoting microvasculature regeneration.
bioRxiv · Oct 27, 2022 · PreprintMolecular Biology