Sandra Curras-Alonso

This study uses single-cell RNA sequencing to show that radiotherapy induces pro-angiogenic signaling in human lung tissue, including upregulation of VEGFA and changes in capillary and macrophage populations.

This paper introduces ComSeg, a segmentation algorithm for image-based spatial transcriptomics that outperforms existing methods in cell type calling and handles complex tissue structures.

The paper shows that inducing telomerase in p21-positive cells in aging mice lungs reduces capillary rarefaction and improves lung function by promoting microvasculature regeneration.

This study shows that telomerase expression in old mice prevents emphysema by maintaining endothelial and AT2 cell populations through increased proliferation.