Charles Fouillade

This paper shows that varying second-scale inter-pulse intervals in pulsed fast fractionation (PFF) with VHEE radiation can differentially modulate normal tissue toxicity and cell viability in vitro and in vivo.

This study compares the radiobiological effects of Very High Energy Electrons (VHEE) from a laser-plasma accelerator with Conventional Intermediate Energy Electrons (CIEE) from a linear accelerator across in vitro, ex vivo, and in vivo models, finding no significant differences in toxicity.

This study identifies Hippo/YAP and Notch signaling coordination as essential for tissue architecture-driven cell fate decisions in bi-layered epithelia during development and regeneration.

autoFISH provides a modular toolbox for automated smFISH experiments, including equipment plans, software, protocols, and analysis workflows validated on cell lines and tissues.

This study uses single-cell RNA sequencing to show that radiotherapy induces pro-angiogenic signaling in human lung tissue, including upregulation of VEGFA and changes in capillary and macrophage populations.

This paper introduces ComSeg, a segmentation algorithm for image-based spatial transcriptomics that outperforms existing methods in cell type calling and handles complex tissue structures.

The paper provides a DIY guide for image-based spatial transcriptomics using TLS as an example, covering experimental design, wet lab methods, and analysis.

The paper shows that inducing telomerase in p21-positive cells in aging mice lungs reduces capillary rarefaction and improves lung function by promoting microvasculature regeneration.

This study shows that telomerase expression in old mice prevents emphysema by maintaining endothelial and AT2 cell populations through increased proliferation.