Author

Sara Kohnke

University of CambridgeORCID 0000-0002-0063-9037Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:clustering· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Clémence BlouetiD· 3 shared Brian LamiD· 2 shared Giles S.H. YeoiD· 2 shared Sophie A BulleriD· 2 shared Anthony P. ColliD· 1 shared Chao ZhaoiD· 1 shared Chiara CossettiiD· 1 shared Danaé Nuzzaci· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Clémence BlouetORCID

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3 papers

Recent·Most cited

Median eminence myelin continuously turns over in adult mice

Sophie A Buller, Sara Kohnke, Robert Hansford, Takahiro Shimizu, William David Richardson, Clémence Blouet

This study shows that myelin in the adult mouse median eminence continuously turns over, regulated by nutritional status and microglia.

Molecular Metabolism · Feb 4, 2023Peer-reviewedNeuroscience

Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence

Sara Kohnke, Brian Lam, Sophie A Buller, Chao Zhao, Danaé Nuzzaci, John A. Tadross, Staffan Holmqvist, Katherine Ridley, Hannah A. Hathaway, Wendy B. Macklin, Giles S.H. Yeo, Robin J.M. Franklin, David H. Rowitch, Clémence Blouet

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.

bioRxiv · Sep 1, 2019 · PreprintNeuroscience

Heterogeneity of hypothalamic Pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Brian Lam, Irène Cimino, Joseph Polex-Wolf, Sara Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luís R. Saraiva, Darren W. Logan, Clémence Blouet, Stephen O’Rahilly, Anthony P. Coll, Giles S.H. Yeo

The paper uses single-cell RNA sequencing to reveal heterogeneity in murine hypothalamic POMC neurons, identifying distinct subpopulations with different gene expression profiles and receptor expression.

Molecular Metabolism · Mar 1, 2017Peer-reviewedNeuroscience