Zoi Lygerou

The paper presents a stochastic hybrid model of DNA replication in fission yeast that incorporates protein mobility dynamics and experimental data to simulate full-genome duplication and replication timing.

This study identifies McIdas as a regulator of centriole numbers through PLK4-dependent phosphorylation, linking its role in cell cycle control to centriole duplication.

The paper presents a stochastic hybrid model of DNA re-replication in fission yeast, showing cell-to-cell heterogeneity and genome plasticity through simulations and experimental validation.

This study shows that aberrant replication licensing factors drive Copy Number Gains (CNGs) in fission yeast and mammalian cells, linking re-replication to cancer and evolution.

The paper shows that Cdt2 binds PCNA via a PIP box, enhancing CRL4Cdt2 activity and Cdt1 ubiquitination, suggesting a new mechanism for substrate targeting.