Author

Akiyo Hayashi

University of HyogoORCID 0000-0003-1900-4282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Hideo NishitaniiD· 2 shared Yasushi ShiomiiD· 2 shared Anastassis Perrakis AiD· 1 shared Christophe CaillatiD· 1 shared Eleonore von CastelmuriD· 1 shared Magda Stadnik-SpiewakiD· 1 shared Masato T. KanemakiiD· 1 shared Michiyo Takahara· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Hideo NishitaniORCID

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2 papers

Recent·Most cited

The depletion of TRAIP results in the retention of PCNA on chromatin during mitosis, leads to inhibiting DNA replication initiation.

Yasushi Shiomi, Akiyo Hayashi, Yuichiro Saito, Masato T. Kanemaki, Hideo Nishitani

This study shows that TRAIP depletion causes PCNA retention on chromatin during mitosis, leading to reduced Cdt1 levels and impaired S phase entry.

Genes to Cells · Feb 16, 2025Peer-reviewedMolecular Biology

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

Akiyo Hayashi, Nikolaos-Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Ανδρέας Παναγόπουλος, Christophe Caillat, Michiyo Takahara, Richard G. Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro S. Takahashi, Yasushi Shiomi, Stavros L. Taraviras, Eleonore von Castelmur, Zoi Lygerou, , Hideo Nishitani

The paper shows that Cdt2 binds PCNA via a PIP box, enhancing CRL4Cdt2 activity and Cdt1 ubiquitination, suggesting a new mechanism for substrate targeting.

Life Science Alliance · Dec 1, 2018Peer-reviewedMolecular Biology