Author

Lucas A. Runyan

The Ohio State UniversityORCID 0000-0001-5690-7849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Dmitri S. KudryashoviD· 2 shared Elena KudryashovaiD· 2 shared E. S. NiedzialkowskaiD· 1 shared Edward H. EgelmaniD· 1 shared Mubarik Mohamed· 1 shared Richa AgrawaliD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

Dmitri S. KudryashovORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Molecular BiologyPeer-reviewedJun 25, 2025

Human plastins are novel cytoskeletal pH sensors with a reduced F-actin bundling capacity at basic pH

Lucas A. Runyan, Elena Kudryashova, Richa Agrawal…·Dmitri S. Kudryashov

This paper identifies plastins as novel cytoskeletal pH sensors that reduce F-actin bundling at alkaline pH, affecting actin dynamics and potentially contributing to cancer progression.

3 citations

humanproteomics

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BiochemistrybioRxivPreprintDec 26, 2023

Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin

E. S. Niedzialkowska, Lucas A. Runyan, Elena Kudryashova…·Dmitri S. Kudryashov

This study shows that Salmonella effector SipA stabilizes F-actin through a unique binding mechanism, similar to inorganic phosphate and phalloidin, enhancing toxin effects while avoiding host detection.

DOI 10.1101/2023.12.26.573373

structural biologyexperimental assay

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