A conformational fingerprint for amyloidogenic light chains.
Cristina Paissoni, Sarita Puri, Luca Broggini, Manoj Kumar Sriramoju, Martina Maritan, Rosaria Russo, Valentina Speranzini, Federico Ballabio, Mario Nuvolone, Giampaolo Merlini, Giovanni O. Palladini, Shang‐Te Danny Hsu, Stéfano Ricagno, Carlo Camilloni
This study identifies a conformational fingerprint distinguishing AL from MM light chains using SAXS and MD simulations, revealing a unique H state in AL LCs.
bioRxiv · Jul 12, 2024Biophysics