Author

Nicholas Sim

Nanyang Technological UniversityORCID 0000-0001-5710-3762Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Benita Kiat Tee TaniD· 1 shared Jean-Michel CarteriD· 1 shared Kamalakshi DekaiD· 1 shared Suet‐Mien TaniD· 1 shared Yinghui LiiD· 1 shared Yirong SimiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

Benita Kiat Tee TanORCID

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1 paper

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedJul 5, 2024

TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in Triple-Negative Breast Cancer

Nicholas Sim, Jean-Michel Carter, Kamalakshi Deka…·Yinghui Li

This study shows that TWEAK/Fn14 signalling rewires the transcriptomic and epigenomic landscape of TNBC, promoting metastasis through super-enhancer-driven metabolic reprogramming.

37 citationstop 3%

humanbulk RNA-seq

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