Yang Li

This study improves gene expression prediction models by incorporating tandem repeats, showing significant performance gains and identifying nonlinear effects on gene expression.

This paper introduces a haplotype-based fine-mapping method called happler to identify causal variants for complex traits, showing improved performance over traditional methods in detecting haplotype effects.

This study identifies STRs associated with alternative splicing in human brain tissue and links some to disease-related GWAS signals.

The paper identifies 119 high-confidence STR-trait associations across 93 STRs for blood and serum traits using imputed genotypes from UK Biobank data.

The paper creates a deep population reference panel of tandem repeat variation using whole genome sequencing and develops a method to genotype over 1.7 million TR loci, identifying novel eQTL signals and a phased haplotype panel for imputation.

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

The paper tracks replicative aging in yeast cells and finds that intermittent heterochromatin silencing loss regulates lifespan, with Sir2 deacetylase playing a key role.