Lev S. Tsimring

This study develops a mathematical model to analyze how environmental glucose fluctuations influence yeast aging and identifies strategies to enhance cellular longevity.

This study investigates how dynamic interferon-gamma stimulation affects pro-inflammatory gene expression in macrophages, revealing gene-specific response patterns and stochasticity in CXCL10 expression.

The paper develops a dynamical model to identify optimal gene regulation strategies for cellular responses to environmental shifts based on selective pressures.

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

This paper designs gene circuits to control spatiotemporal growth phenotype patterns in microbial colonies, demonstrating oscillations between growth and dormancy and enabling selective gene expression in non-dividing cells.

The paper tracks replicative aging in yeast cells and finds that intermittent heterochromatin silencing loss regulates lifespan, with Sir2 deacetylase playing a key role.

This paper introduces a method for rapidly producing bacterial lysates for cell-free gene expression using autolysis and freeze-thaw or freeze-dry cycles, enabling scalable and cost-effective biosensor development.