Richard O’Laughlin

The paper develops a framework using evolved microbial diversity and machine learning to enable combinatoric biosensing of multiple analytes in complex environments.

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

The paper tracks replicative aging in yeast cells and finds that intermittent heterochromatin silencing loss regulates lifespan, with Sir2 deacetylase playing a key role.