Takashi Nonaka

The 329HHK331 motif is essential for Alzheimer's disease tau filament fold

The paper investigates the role of the 329HHK331 motif in Alzheimer's disease tau filament formation and shows that mutations in this region affect filament structure and seeding activity.

α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron-microglia communication

This study shows that α-synuclein aggregates cause mitochondrial damage and activate innate immunity, leading to neuron-microglia communication via TNTs and promoting disease progression in Synucleinopathies.

Neuronal Autophagy Failure Drives α-Synuclein Transfer to Microglia to Outsource Aggregate Clearance

The paper shows that neuronal autophagy failure leads to α-synuclein aggregate transfer to microglia, which then degrade them more efficiently.

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C

This study identifies heteromeric amyloid filaments composed of ANXA11 and TDP-43 in FTLD-TDP Type C using cryo-EM, revealing a new pathological mechanism.

α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome

The paper shows that different α-synuclein strains cause distinct pathologies by differentially inhibiting proteasome activity through structural differences in their C-terminal regions.