Ricardo C. Ferreira

The paper investigates how HLA-DQβ157 polymorphism influences T cell receptor selection and links it to microbial antigens that mimic insulin, contributing to type 1 diabetes pathogenesis.

The paper identifies deleterious neutrophil states and altered granulopoiesis in sepsis using single-cell multi-omics data from sepsis patients and controls.

The paper shows that HLA class II haplotypes influence T1D risk by selecting for CD4+ T cell receptors with negatively charged CDR3β sequences that bind insulin, and demonstrates this in peripheral and islet T cells.

The paper uses single-cell multi-omics to analyze T and NK cells in SLE patients, identifying IFN-driven changes and novel biomarkers.

The paper identifies autoimmune disease candidate genes by integrating promoter capture Hi-C data with genetic associations in activated CD4+ T cells.