Arcadio Rubio García

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

The paper identifies a genetic variant that affects transcription factor binding and reduces type 1 diabetes risk in infants by altering thymic gene expression.

Autoimmune interactions between the HLA-DQβ157 polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes

The paper investigates how HLA-DQβ157 polymorphism influences T cell receptor selection and links it to microbial antigens that mimic insulin, contributing to type 1 diabetes pathogenesis.

HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection

The paper shows that HLA class II haplotypes influence T1D risk by selecting for CD4+ T cell receptors with negatively charged CDR3β sequences that bind insulin, and demonstrates this in peripheral and islet T cells.

DNA methylation oscillation defines classes of enhancers

The paper identifies DNA methylation oscillations as a marker for enhancer classification, showing high predictive power compared to other methods.

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

The paper identifies autoimmune disease candidate genes by integrating promoter capture Hi-C data with genetic associations in activated CD4+ T cells.