Author

Agnieszka Szypowska

Medical University of WarsawORCID 0000-0002-3407-3174Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1

Frequent Co-Authors

Arcadio Rubio GarcíaiD· 2 shared Athina PaterouiD· 2 shared Dominik Trzupek· 2 shared Hubert SlawinskiiD· 2 shared John A. ToddiD· 2 shared Laurie G. LandryiD· 2 shared Linda S. WickeriD· 2 shared Luc TeytoniD· 2 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Arcadio Rubio GarcíaORCID

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2 papers

Recent·Most cited

Autoimmune interactions between the HLA-DQβ157 polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes

Arcadio Rubio García, Athina Paterou, Rebecca Powell Doherty, Laurie G. Landry, Mercede Lee, Amanda M. Anderson, Claire L. Scudder, Hubert Slawinski, Ricardo C. Ferreira, Dominik Trzupek, Agnieszka Szypowska, Luc Teyton, Nicola Ternette, Maki Nakayama, Linda S. Wicker, , Marcin Ł. Pękalski

The paper investigates how HLA-DQβ157 polymorphism influences T cell receptor selection and links it to microbial antigens that mimic insulin, contributing to type 1 diabetes pathogenesis.

medRxiv · May 11, 2022 · PreprintGenetic & Genomic Medicine

HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection

Arcadio Rubio García, Athina Paterou, Mercede Lee, Hubert Slawinski, Ricardo C. Ferreira, Laurie G. Landry, Dominik Trzupek, Luc Teyton, Agnieszka Szypowska, Linda S. Wicker, Maki Nakayama, John A. Todd, Marcin Ł. Pękalski

The paper shows that HLA class II haplotypes influence T1D risk by selecting for CD4+ T cell receptors with negatively charged CDR3β sequences that bind insulin, and demonstrates this in peripheral and islet T cells.

bioRxiv · Sep 6, 2021 · PreprintGenomics