Biola M. Javierre

Three-Dimensional Epigenome Roadmap of Human B-cell Differentiation Uncovers Mechanisms of Humoral Immunity and Oncogenesis

This paper creates a 3D epigenomic roadmap of human B-cell differentiation, revealing regulatory mechanisms in immunity and cancer.

Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomics

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.

Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments

The paper shows that environmental enrichment modulates age-related changes in the 3D chromatin interactome of mouse hippocampal neurons, inducing maturation in young mice and partial rejuvenation in old mice.

p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

This study shows p53 rapidly changes 3D chromatin structure to regulate gene transcription, identifying 340 new direct target genes.

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution

The paper introduces liCHi-C, a low-input Hi-C method, to map promoter-enhancer interactions in clinical samples and identify disease-relevant regulatory elements and structural variants.

High-resolution simulations of chromatin folding at genomic rearrangements in malignant B-cells provide mechanistic insights on proto-oncogene deregulation

The paper uses polymer simulations to study chromatin structure changes at genomic rearrangements in B-cells and shows how these changes affect proto-oncogene expression.

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

The paper links diabetes-associated enhancers with their target genes using 3D chromatin architecture in human pancreatic islets, revealing genetic variants that impact insulin secretion heritability.

Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility

The paper identifies how variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility and cell count differences.

DNA methylation oscillation defines classes of enhancers

The paper identifies DNA methylation oscillations as a marker for enhancer classification, showing high predictive power compared to other methods.

Heterogeneous chromatin mobility derived from chromatin states is a determinant of genome organisation in S. cerevisiae

The paper shows that differential mobility of chromatin segments, influenced by protein occupancy, drives 3D genome organisation in yeast.

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

The paper identifies autoimmune disease candidate genes by integrating promoter capture Hi-C data with genetic associations in activated CD4+ T cells.