Author

Dominik Trzupek

Centre for Human Genetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

John A. ToddiD· 4 shared Linda S. WickeriD· 4 shared Mercede LeeiD· 4 shared Ricardo C. FerreiraiD· 4 shared Marcin Ł. PękalskiiD· 3 shared Agnieszka SzypowskaiD· 2 shared Arcadio Rubio GarcíaiD· 2 shared Athina PaterouiD· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

John A. ToddORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Autoimmune interactions between the HLA-DQβ157 polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes

Arcadio Rubio García, Athina Paterou, Rebecca Powell Doherty, Laurie G. Landry, Mercede Lee, Amanda M. Anderson, Claire L. Scudder, Hubert Slawinski, Ricardo C. Ferreira, Dominik Trzupek, Agnieszka Szypowska, Luc Teyton, Nicola Ternette, Maki Nakayama, Linda S. Wicker, , Marcin Ł. Pękalski

The paper investigates how HLA-DQβ157 polymorphism influences T cell receptor selection and links it to microbial antigens that mimic insulin, contributing to type 1 diabetes pathogenesis.

medRxiv · May 11, 2022 · PreprintGenetic & Genomic Medicine

Low-dose IL-2 reduces IL-21+ T cells and induces a long-lived anti-inflammatory gene expression signature inversely modulated in COVID-19 patients

Jiayuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H. M. Yang, Marcin Ł. Pękalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

medRxiv · Apr 5, 2022 · PreprintGenetic & Genomic Medicine

HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection

Arcadio Rubio García, Athina Paterou, Mercede Lee, Hubert Slawinski, Ricardo C. Ferreira, Laurie G. Landry, Dominik Trzupek, Luc Teyton, Agnieszka Szypowska, Linda S. Wicker, Maki Nakayama, John A. Todd, Marcin Ł. Pękalski

The paper shows that HLA class II haplotypes influence T1D risk by selecting for CD4+ T cell receptors with negatively charged CDR3β sequences that bind insulin, and demonstrates this in peripheral and islet T cells.

bioRxiv · Sep 6, 2021 · PreprintGenomics

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and Natural Killer cells in systemic lupus erythematosus

Dominik Trzupek, Mercede Lee, Fiona Hamey, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

The paper uses single-cell multi-omics to analyze T and NK cells in SLE patients, identifying IFN-driven changes and novel biomarkers.

medRxiv · Apr 27, 2021 · PreprintGenetic & Genomic Medicine