Lu Bai

This study compares ATAC-seq and MNase-seq in budding yeast, showing they detect distinct chromatin states and functional roles in gene regulation.

The paper shows that cohesin facilitates nucleosome invasion by transcription factors, even in the absence of chromatin remodeling or replication.

This study uses a chemical method to create controlled chromosomal interactions in yeast to assess Hi-C's quantitative properties, finding it sensitive, unbiased, and linear.

This study measures chromosomal encounter times in budding yeast using CICI and finds that condensin accelerates long-range intra-chromosomal interactions compared to inter-chromosomal ones.

This paper introduces MTAC, a method to map long-distance chromosomal interactions in yeast, revealing new insights into 3D genome organization.

This study shows that transcription factor condensates cluster target genes and enhance their expression in response to methionine starvation in yeast.

The paper identifies EOMES as a key mediator of WNT priming in human embryonic stem cells, enabling subsequent Activin-induced mesendodermal differentiation.

The paper shows that Ash1 repressor binds to the HO promoter in yeast, requiring nucleosome eviction by Swi5 for access, and that this process is linked to repression and promoter resetting.

The paper shows that the Mediator Tail module can be recruited independently to the HO promoter in yeast, suggesting the core Mediator complex limits coactivator recruitment and gene activation.

The paper introduces CICI, a method to selectively perturb chromosomal interactions in yeast, showing its ability to alter genome functions like DNA repair.

This study investigates how budding yeast pioneer transcription factors bind and dissociate from nucleosomal DNA, showing they compensate for reduced binding by increasing dwell time, similar to human pioneer factors.