Lisa Traunmüller

Bolero predicts cell-state-specific gene regulation from DNA across species by integrating cell-state embeddings and biological variables.

This study shows that ZMYND11 inhibits KMT2A to regulate neuronal development, and a mutation in ZMYND11 disrupts this interaction, leading to developmental and behavioral abnormalities.

The paper shows neuronal activity affects RNA stability, with HuD regulating mRNA abundance and variants linked to neurodevelopmental disorders disrupting this process.

This study identifies cell-type-specific chromatin accessibility and gene expression changes in the hippocampus following novel environment exposure using single-nucleus multiomics and bulk RNA-seq.