Inés Lucía Patop

"Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity in Drosophila"

The paper identifies non-canonical circadian oscillators in Drosophila neurons that exhibit molecular rhythms despite lacking core clock genes.

Neuronal development shapes activity-dependent gene expression in a stimulus-specific manner

The paper examines how neuronal development and different stimulation modalities affect activity-dependent gene expression in neurons.

Neuronal activity triggers widespread changes in RNA stability

The paper shows neuronal activity affects RNA stability, with HuD regulating mRNA abundance and variants linked to neurodevelopmental disorders disrupting this process.

Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea

This study shows mechanical compression induces tissue-like multicellularity in haloarchaea, forming structures with distinct molecular and mechanical features similar to eukaryotic tissues.

Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators

This study shows circRNAs are highly stable in the aging fly brain and can indicate age and environmental experience.

Organismal landscape of clock cells and circadian gene expression in Drosophila

The paper identifies circadian gene expression patterns in Drosophila using single-cell and bulk RNA-seq, revealing three mechanisms for generating daily gene expression rhythms.

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

This study shows that SARS-CoV-2 Nsp14 alters the host transcriptome, splicing, and circRNA levels, with IMPDH2 mediating these effects through GTP regulation.

An in vivo strategy for knockdown of circular RNAs

This paper describes a method to specifically knock down circRNAs in vivo and shows that circRNA downregulation affects fly development and transcriptome.

Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila

This study shows that temperature changes alter the splicing of the timeless gene in Drosophila, affecting TIM protein levels and activity through temperature-sensitive splicing isoforms.

An in vivo knockdown strategy reveals multiple functions for circMbl

This paper develops a shRNA-based strategy to knock down circMbl in Drosophila, revealing its functional roles in development, behavior, and synaptic function.