Leonardo V. Castorina

From Atoms to Fragments: A Coarse Representation for Efficient and Functional Protein Design

This paper introduces a fragment-based representation for proteins that improves functional clustering and search efficiency compared to traditional methods.

HLA Alleles Imprint Distinct Biases in the Usage Preferences of TCR Vβ segments

This study identifies HLA allele-specific biases in TCR Vβ usage, showing germline-encoded preferences shape TCR-HLA compatibility and influence TCR-pHLA specificity.

Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition

The paper analyzes a crowdsourced protein design competition, showing participants designed EGFR binders with varying affinities and highlighting challenges in benchmarking and experimental design.