Brenton R. Graveley

This study identifies 239 snoRNAs in Drosophila S2 cells and maps 2-O-methylation sites using RibOxi-seq2, revealing widespread Nm modifications in rRNAs and mRNAs.

This study shows that reducing Indy gene activity in Drosophila lowers bacterial load and preserves gut homeostasis, extending lifespan through JAK/STAT signaling pathway modulation.

This paper introduces an improved DRS protocol using UltraMarathonRT to generate longer RNA reads and isoform predictions in Oxford Nanopore sequencing.

The paper compares RNA 2'-O-methylation patterns in neurons with and without specific snoRNA deletions, identifying new targets of orphan snoRNAs.

The paper identifies splicing regulatory elements and their associated RNA binding proteins using ENCODE data and experimental assays, validating findings with CRISPR base editors and transcriptomic datasets.

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

The paper analyzes eCLIP data for 150 RBPs in K562 and HepG2 cells, revealing binding modalities, RBP functions, and novel RNA processing mechanisms.

The paper introduces BEAPR, a computational method to detect allele-specific binding of RNA-binding proteins, showing it outperforms existing methods and identifies disease-relevant variants.

The paper develops a high-throughput method to assess how genetic variants affect pre-mRNA splicing efficiency across 110 alternative exons in humans.

The paper introduces END-seq to measure poly(A) tail lengths transcriptome-wide in yeast and shows Ccr4 and Pop2 differentially regulate these tails.