This study shows that reducing Indy gene activity in Drosophila lowers bacterial load and preserves gut homeostasis, extending lifespan through JAK/STAT signaling pathway modulation.

bioRxiv · Mar 26, 2026 · PreprintGenetics

Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden

Emma Camacho, Yuemei Dong, Christine Chrissian, Radamés J. B. Cordero, Raúl G. Saraiva, Yesseinia Angleró-Rodríguez, Daniel F. Q. Smith, Ella Jacobs, Isabella Hartshorn, José Alberto Patiño-Medina, Michael DePasquale, Amanda Dziedzic, Anne Jedlicka, Barbara Smith, Godfree Mlambo, , Arturo Casadevall

This study shows dietary L-DOPA increases melanization, immunity, and reduces lifespan in Anopheles mosquitoes, while lowering malaria parasite burden.

Nature Communications · Aug 27, 2025Peer-reviewedMicrobiology

Modulating DNA Polα Enhances Cell Reprogramming Across Species

Rajesh Ranjan, Binbin Ma, Ryan J. Gleason, Yijun Liao, Yingshan Bi, Brendon E. M. Davis, Guanghui Yang, Maggie Clark, Vikrant Mahajan, Madison Condon, Nichole A. Broderick, Xin Chen

This study shows that reducing DNA Polα levels enhances cell reprogramming across species, improving fertility and tissue regeneration without affecting lifespan.

bioRxiv · Sep 19, 2024 · PreprintDevelopmental Biology

Evaluation of InSeq to Identify Genes Essential for Pseudomonas aeruginosa PGPR2 Corn Root Colonization

R Sivakumar, Jothi Ranjani, Udayakumar S. Vishnu, Sathyanarayanan Jayashree, Gabriel L. Lozano, Jessica Miles, Nichole A. Broderick, Changhui Guan, P. Gunasekaran, Jo Handelsman, Jeyaprakash Rajendhran

This study uses INSeq to identify 108 genes essential for Pseudomonas aeruginosa PGPR2 root colonization, with four genes validated through mutant testing.

G3 Genes Genomes Genetics · Jan 31, 2019Peer-reviewedGenomics