Baylea N. Davenport

This study shows that maternal cortisol elevation due to stress mediates fetal growth restriction in undernourished guinea pigs, beyond just nutrient limitation.

This study shows repeated nanoparticle-mediated IGF1 treatment corrects aberrant placental structure in a guinea pig model of fetal growth restriction, improving fetal growth and placental function.

This study shows that placental hIGF1 nanoparticle treatment in guinea pigs reduces FGR-related kidney structural and signaling pathway changes.

This study shows that placental hIGF1 nanoparticle gene therapy in guinea pigs reduces FGR-associated liver metabolic dysregulation in a fetal sex-specific manner.

This study investigates placental IGF1 signaling and nutrient transport in a guinea pig model of FGR with nanoparticle-mediated IGF1 treatment, showing sex-specific changes and supporting therapeutic potential.

This study examines placental transcriptome changes in a guinea pig model of placental insufficiency with and without hIGF1 nanoparticle treatment, identifying key signaling and metabolic pathways affected.

This paper demonstrates that placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model by improving fetal weight, blood glucose, and reducing cortisol levels.

This study identifies transcriptome changes in the sub-placenta/decidua associated with placental insufficiency and shows that hIGF1 nanoparticle treatment alters gene expression related to trophoblast invasion and homeostasis.

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.