Rebecca L. Wilson

Sustained Maternal Cortisol Elevation Links Metabolic Stress to Fetal Growth Restriction in a Guinea Pig Model of Undernutrition

This study shows that maternal cortisol elevation due to stress mediates fetal growth restriction in undernourished guinea pigs, beyond just nutrient limitation.

Understanding the Causal Impact of Elevated Maternal Stress During Pregnancy: A Systematic Literature Review of Guinea Pig Models

This review evaluates guinea pig models of maternal stress during pregnancy, finding significant fetal effects but limited understanding of maternal physiological adaptations.

Aberrant placental structure is corrected with repeated nanoparticle-mediated IGF1 treatments in a guinea pig model of fetal growth restriction

This study shows repeated nanoparticle-mediated IGF1 treatment corrects aberrant placental structure in a guinea pig model of fetal growth restriction, improving fetal growth and placental function.

A human cytotrophoblast-villous endothelium-fetal organ multi-cell model and the impact on gene and protein expression in placenta cytotrophoblast, fetal hepatocytes and fetal kidney epithelial cells

This study examines the effects of trophoblast stress and hIGF1 nanoparticle gene therapy on gene and protein expression in fetal liver and kidney cells using a co-culture model.

Placenta hIGF1 nanoparticle treatment in guinea pigs mitigates fetal sex dependent FGR-associated effects on kidney structure and blood pressure-related signaling pathways

This study shows that placental hIGF1 nanoparticle treatment in guinea pigs reduces FGR-related kidney structural and signaling pathway changes.

Placental hIGF1 nanoparticle gene therapy in guinea pigs ameliorates fetal growth restriction-associated changes in hepatic lipid and glucose metabolism-related signaling pathways in a fetal sex-specific manner

This study shows that placental hIGF1 nanoparticle gene therapy in guinea pigs reduces FGR-associated liver metabolic dysregulation in a fetal sex-specific manner.

Placental Nutrient Transport and Signaling in a Guinea Pig Model of Fetal Growth Restriction with Repeated Placental Nanoparticle-mediated IGF1 Treatment

This study investigates placental IGF1 signaling and nutrient transport in a guinea pig model of FGR with nanoparticle-mediated IGF1 treatment, showing sex-specific changes and supporting therapeutic potential.

Mid-pregnancy placental transcriptome in a model of placental insufficiency with and without novel intervention

This study examines placental transcriptome changes in a guinea pig model of placental insufficiency with and without hIGF1 nanoparticle treatment, identifying key signaling and metabolic pathways affected.

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

This paper demonstrates that placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model by improving fetal weight, blood glucose, and reducing cortisol levels.

Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention

This study identifies transcriptome changes in the sub-placenta/decidua associated with placental insufficiency and shows that hIGF1 nanoparticle treatment alters gene expression related to trophoblast invasion and homeostasis.

Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.

HAND1 knockdown disrupts trophoblast global gene expression

This study shows that HAND1 knockdown affects gene expression in trophoblast cells but not endothelial cells, highlighting the importance of extra-embryonic tissue in CHD research.

Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease