Author

Elske H. P. Franssen

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

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Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ákos VégváriiD· 1 shared Alexander Georg NickeliD· 1 shared Andrea DegasperiiD· 1 shared Anna WalentinssoniD· 1 shared Christer BetsholtziD· 1 shared Christoph MaackiD· 1 shared Claus BendtseniD· 1 shared Dominique KoppenhöferiD· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperMolecular Biology

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1 paper

Recent·Most cited

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function

Zaher Elbeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca E. Jarvis, Roland W. Bürli, Tanguy Jamier, Elske H. P. Franssen, Mike A. Firth, Andrea Degasperi, Claus Bendtsen, , Christer Betsholtz

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

Nature Communications · Mar 20, 2024Peer-reviewedMolecular Biology