Arno Ruusalepp

The paper identifies tissue-specific protein regulation and pQTLs associated with cardiometabolic disease using multi-tissue proteomic data from STARNET patients.

The paper identifies genetic variants associated with plasma cortisol and cardiovascular disease, revealing gene networks in liver and adipose tissues regulated by corticosteroid binding globulin and the glucocorticoid receptor.

This study identifies Cystatin C as a glucocorticoid-responsive factor that recruits Trem2+ macrophages and predicts immunotherapy failure in cancer.

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

This paper evaluates transcriptome-wide association studies (TWAS) for causal gene prioritization, showing its strengths and limitations in identifying causal genes at GWAS loci.

EnsembleCNV improves CNV detection and genotyping using SNP arrays, achieving high accuracy and sensitivity for downstream GWAS.