Moritz von Scheidt

Intraindividual longitudinal changes of the proteome reveal dynamic markers of biological aging

The paper develops a proteomic aging clock using longitudinal plasma proteomics data to show that biological aging is dynamically influenced by modifiable risk factors.

A cell type-resolved proteomic atlas of the human body

The paper constructs a cell type-resolved proteomic atlas of the human body using Deep Visual Proteomics, revealing protein abundance patterns and uncovering cancer-testis antigens in oocytes.

Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

Cancer drives atherosclerotic plaque vulnerability by inducing pathological angiogenesis

This study shows cancer increases atherosclerotic plaque vulnerability through pathological angiogenesis, and targets this pathway to prevent plaque destabilization.

Cigarette smoking upregulates vascular expression of the novel atherosclerosis risk factor ADAMTS-7

This study shows cigarette smoke increases vascular ADAMTS7 expression through CCL17-CCR4 signaling, linking smoking to atherosclerosis via a novel gene-environment interaction.

Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking Insights

This study identifies novel and known genetic contributors to hypertension using RNA-seq and eQTL analyses, highlighting potential drug targets and pathways.

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.