The paper develops a proteomic aging clock using longitudinal plasma proteomics data to show that biological aging is dynamically influenced by modifiable risk factors.

bioRxiv · Oct 6, 2026 · PreprintBioinformatics

Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci

Dennis Hecker, Xiaoning Song, Nina Baumgarten, Anastasiia Diagel, Nikoletta Katsaouni, Ling Li, Shuangyue Li, Ranjan Kumar Maji, Fatemeh Behjati Ardakani, Lijiang Ma, Zhaolong Li, Aldo Moggio, Daniel Tews, Hendrik Sager, Lars Mäegdefessel, , Marcel H. Schulz

The paper identifies 1,580 cell type-specific genes and non-coding RNAs associated with coronary artery disease by integrating genetic and epigenetic data from multiple cell types.

Nature Communications · Mar 10, 2026Peer-reviewedBioinformatics

A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

Tristan V. de Jong, Yanchao Pan, Pasi M. A. Rastas, Daniel B. Munro, Monika Tutaj, Huda Akil, Christopher W. Benner, Denghui Chen, Apurva S. Chitre, William Chow, Vincenza Colonna, Clifton L. Dalgard, Wendy Demos, Peter A. Doris, Erik P. Garrison, , Hao Chen

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

Cell Genomics · Mar 26, 2024Peer-reviewedGenomics

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons Jake Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, , Heribert Schunkert

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

Basic Research in Cardiology · Feb 17, 2022Peer-reviewedGenetics

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

Krishna G. Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Elle M. Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas Marston, Frederick Kamanu, Ida L. Surakka, Loreto Muñoz Venegas, , Adam S. Butterworth

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

medRxiv · May 24, 2021 · PreprintGenetic & Genomic Medicine✦ In-depth digest

Cis-epistasis at the LPA locus and risk of coronary artery disease

Lingyao Zeng, Nazanin Mirza‐Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Oscar Franzén, Marcus Edi Kleber, Salome Rebecca Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, , Heribert Schunkert

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.

bioRxiv · Jan 23, 2019 · PreprintGenetics