BioengineeringNature CommunicationsPeer-reviewed
Cardiac Reprogramming with Drug Resistance Alleviates Doxorubicin-induced Cardiotoxicity in Mice and Pigs
Yixin Zhang, Wenhua Li, Yingxian Xiao…·Zhenhua Li
This paper introduces a strategy called TopCare to reduce doxorubicin-induced cardiotoxicity by temporarily increasing P-gp expression in cardiomyocytes, showing improved survival and cardiac function in mice and pigs.
DOI 10.1038/s41467-026-71843-9