Cardiac Reprogramming with Drug Resistance Alleviates Doxorubicin-induced Cardiotoxicity in Mice and Pigs
Yixin Zhang, Wenhua Li, Yingxian Xiao, Li Luo, Jiacong Ai, Shushan Mo, Lanya Li, Junyao Deng, Xueyi Wang, Qian Li, Yan Zeng, Huifang Liu, Fei Wang, Zhenhua Li
This paper introduces a strategy called TopCare to reduce doxorubicin-induced cardiotoxicity by temporarily increasing P-gp expression in cardiomyocytes, showing improved survival and cardiac function in mice and pigs.
Nature Communications · Apr 15, 2026Peer-reviewedBioengineering