Author

Sam Nooij

Leiden UniversityORCID 0000-0001-5892-5637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:metagenomics· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Ed J. KuijperiD· 2 shared Ingrid M. J. G. Sanders· 2 shared Quinten R. DucarmoniD· 2 shared Rolf H. A. M. Vossen· 2 shared Susan L. KloetiD· 2 shared Wiep Klaas SmitsiD· 2 shared A. E. van der MeuleniD· 1 shared Aldert ZomeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

Ed J. KuijperORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyFEMS MicrobesPeer-reviewedJan 1, 2026

Characterization of the clade 4 non-toxigenic C. difficile isolate L-NTCD03 carrying the cfr(B) gene

Britt Nibbering, Sam Nooij, Céline Harmanus…·Wiep Klaas Smits

The paper characterizes a non-toxigenic C. difficile strain, L-NTCD03, showing antimicrobial resistance and non-toxicity, suggesting its potential as a live biotherapeutic.

DOI 10.1093/femsmc/xtag010

C. eleganswhole-genome sequencing

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BioinformaticsbioRxivPreprintDec 5, 2025

MetaPointFinder: Detection of Antimicrobial Resistance-Conferring Point Mutations (ARMs) from Metagenomic Reads

Aldert Zomer, Sam Nooij, Cailean Carter, Alison E. Mather

MetaPointFinder detects antimicrobial resistance-conferring point mutations from metagenomic reads, outperforming existing methods in simulated data.

1 citation

metagenomicsstatistical model

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MicrobiologyNature CommunicationsPeer-reviewedJan 30, 2025

Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status

Sam Nooij, Niels Plomp, Ingrid M. J. G. Sanders…·Quinten R. Ducarmon

The paper surveys Ruminococcus gnavus distribution across host lifestyles and health, revealing higher prevalence in Westernized populations and genomic differences between healthy and Crohn's disease isolates.

33 citationstop 1%

humanmetagenomics

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