Hans‐Georg Koch

This paper develops photocaged MSN analogues that can be delivered into E. coli, photo-released, and tracked to study their metabolic effects.

This study uses CE-MS to profile (p)ppGpp and dinucleoside polyphosphates in bacteria, revealing oscillatory dynamics and potential synchronization between alarmones.

This study identifies YohP as a small membrane protein in E. coli that induces membrane depolarization and (p)ppGpp accumulation, leading to metabolic silencing under stress.

The paper identifies a post-transcriptional mechanism in Rhodobacter capsulatus where Cu-induced ribosomal stalling of CutF controls CutO production by melting an mRNA stem-loop.

The paper identifies YqjD/ElaB/YgaM as ribosome-hibernating proteins that inhibit translation by blocking the ribosomal tunnel, similar to antimicrobial peptides and macrolide antibiotics.

This study shows that the membrane toxin TisB in E. coli causes protein aggregation, which enhances cellular dormancy and antibiotic tolerance.