NeuroscienceMolecular NeurodegenerationPeer-reviewed
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons
Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble…·Ling Hao
This study uses proteomic techniques to show that PGRN deficiency impairs lysosomal function and proteostasis in neurons by altering pH, enzyme levels, and protein turnover.