Author

Stewart W. Humble

National Institutes of HealthORCID 0000-0002-7789-5549Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Brent James RyaniD· 2 shared Richard Wade‐MartinsiD· 2 shared Albert KoulmaniD· 1 shared Andrew Davis· 1 shared Ashley M. FrankenfieldiD· 1 shared Benjamin JenkinsiD· 1 shared David Smith· 1 shared Dean G. BrowniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Brent James RyanORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 1, 2026

Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target

Maria Claudia Caiazza, Janine Brandes, Elizabeth R. Barrow…·Richard Wade‐Martins

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

DOI 10.64898/2026.10.27.761977

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceMolecular NeurodegenerationPeer-reviewedNov 16, 2023

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons

Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble…·Ling Hao

This study uses proteomic techniques to show that PGRN deficiency impairs lysosomal function and proteostasis in neurons by altering pH, enzyme levels, and protein turnover.

44 citationstop 1%

humanmouse

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