Author

Saadia Hasan

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Michael Emmerson WardiD· 3 shared Ashley M. FrankenfieldiD· 2 shared Ling HaoiD· 2 shared Michael S. FernandopulleiD· 2 shared Ahmad Galuta· 1 shared Alick Pingbei WangiD· 1 shared Annemarie DedekiD· 1 shared Archana YadaviD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Michael Emmerson WardORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons

Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent James Ryan, Richard Wade‐Martins, Michael Emmerson Ward, Ling Hao

This study uses proteomic techniques to show that PGRN deficiency impairs lysosomal function and proteostasis in neurons by altering pH, enzyme levels, and protein turnover.

Molecular Neurodegeneration · Nov 16, 2023Peer-reviewedNeuroscience

A Cellular Taxonomy of the Adult Human Spinal Cord

Archana Yadav, Kaya J.E. Matson, Li Li, Isabelle Hua, Joana Petrescu, Kristy Kang, Mor R. Alkaslasi, Dylan I. Lee, Saadia Hasan, Ahmad Galuta, Annemarie Dedek, Sara Ameri, Jessica Parnell, Mohammad M. Alshardan, Feras Abbas Qumqumji, , Ariel J. Levine

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

Neuron · Feb 1, 2023Peer-reviewedNeuroscience

Development and Comparative Evaluation of Endolysosomal Proximity Labeling-based Proteomic Methods in Human iPSC-derived Neurons

Ashley M. Frankenfield, Michael S. Fernandopulle, Saadia Hasan, Michael Emmerson Ward, Ling Hao

The paper develops and evaluates a proximity labeling method to study the endolysosomal proteome in human neurons, showing improved data normalization and complementary coverage compared to overexpression approaches.

Analytical Chemistry · Nov 17, 2020Peer-reviewedSystems Biology