Author

Weijie Du

Humboldt-Universität zu BerlinORCID 0000-0001-5924-8631Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Weijie Du1 paper · University of Iowa

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dimitrios L. WagneriD· 2 shared Jonas KathiD· 2 shared Maik SteiniD· 2 shared Viktor GlaseriD· 2 shared Ana-Maria NitulescuiD· 1 shared Carla Fuster‐GarcíaiD· 1 shared Clemens FrankeiD· 1 shared Elmar JaeckeliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Dimitrios L. WagnerORCID

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2 papers

Recent·Most cited

ImmunologyMolecular Therapy — Nucleic AcidsPeer-reviewedMay 19, 2025

Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells

Ana-Maria Nitulescu, Weijie Du, Viktor Glaser…·Dimitrios L. Wagner

This study improves CRISPR-Cas12a knock-in efficiency in human T cells by using single-stranded DNA templates with double-stranded Cas-target-sequences, achieving up to 90% knock-in rates for transgene inserts.

9 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologyMolecular TherapyPeer-reviewedFeb 3, 2025

Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

Weijie Du, Fatih Noyan, Oliver McCallion…·Dimitrios L. Wagner

This paper develops a non-viral CRISPR-Cas12a method to redirect Tregs with CARs by integrating an antigen-binding domain into the CD3 epsilon gene, showing improved antigen-specific function and graft protection in a mouse model.

17 citationstop 4%

𝕏 PostBluesky