Author

Carla Fuster‐García

University of FreiburgORCID 0000-0002-4209-7248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Dimitrios L. WagneriD· 2 shared Hans‐Dieter VolkiD· 2 shared Jonas KathiD· 2 shared Maik SteiniD· 2 shared Petra ReinkeiD· 2 shared Toni CathomeniD· 2 shared Viktor GlaseriD· 2 shared Yaolin PuiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Dimitrios L. WagnerORCID

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2 papers

Recent·Most cited

Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocations

Viktor Glaser, Lily Jo Becker, Carla Fuster‐García, Luis Huth, Ana-Maria Nitulescu, Yaolin Pu, Isabell Kassing, Laura Marie Hartmann, Christian Luca Flugel, Roberts Kārkliņš, Shona Maria Shaji, Marie Pouzolles, Maik Stein, Geoffroy Andrieux, Toni Cathomen, , Dimitrios L. Wagner

This paper develops BEKI, a base editor-based method for targeted transgene insertion and multiplex gene disruption in T cells, reducing chromosomal translocations compared to Cas9-based approaches.

bioRxiv · Sep 15, 2025 · PreprintSynthetic Biology

Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

Weijie Du, Fatih Noyan, Oliver McCallion, Vanessa Drosdek, Jonas Kath, Viktor Glaser, Carla Fuster‐García, Mingxing Yang, Maik Stein, Clemens Franke, Yaolin Pu, Olaf Weber, Julia K. Polansky, Toni Cathomen, Elmar Jaeckel, , Dimitrios L. Wagner

This paper develops a non-viral CRISPR-Cas12a method to redirect Tregs with CARs by integrating an antigen-binding domain into the CD3 epsilon gene, showing improved antigen-specific function and graft protection in a mouse model.

Molecular Therapy · Feb 3, 2025Peer-reviewedImmunology