Sex-Specific Remodeling Phenotypes of the Tricuspid Valve Leaflets in an Ovine Model of Functional Tricuspid Regurgitation
Colton J. Kostelnik, Magda Piekarska, Shreya Sreedhar, Chien-Yu Lin, Aarya Shah, Bogusław Gawęda, Austin Goodyke, Yujun Xu, Kartik Balachandran, Layla M. Parast, Matthew R. Bersi, Tomasz A. Timek, Manuel K. Rausch
This study investigates sex-specific tricuspid valve leaflet remodeling in an ovine model of functional tricuspid regurgitation, revealing distinct structural, mechanical, and transcriptional responses across sexes and castration status.
bioRxiv · Aug 6, 2026 · PreprintBioengineering