Author

Weijun Gui

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & TechnologyORCID 0000-0001-5936-8262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 1

Frequent Co-Authors

Thomas J. KodadekiD· 2 shared Allison GossiD· 1 shared Bin-Bin SchelliD· 1 shared Hiruni Kandambi· 1 shared Isuru M. JayalathiD· 1 shared Janitha Kumarathunga· 1 shared Joel TongiD· 1 shared Kate E Young· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Thomas J. KodadekORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 14, 2026

A Proximity-Driven Functional Screening Platform for the Discovery of Noninhibitory USP7 Ligand Enabling Targeted Protein Stabilization

Kate E Young, Janitha Kumarathunga, Hiruni Kandambi…·Weijun Gui

This paper introduces a proximity-driven screening platform to identify noninhibitory DUB ligands, discovering a USP7 ligand that enables targeted protein stabilization.

DOI 10.64898/2026.09.10.750156

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryJournal of the American Chemical SocietyPeer-reviewedAug 21, 2025

A Functional Assay For Mining Non-Inhibitory Enzyme Ligands From One Bead One Compound Libraries: Application to E3 Ubiquitin Ligases

Weijun Gui, Allison Goss, Thomas J. Kodadek

The paper introduces a functional assay to identify non-inhibitory enzyme ligands from bead-displayed compound libraries, applied to E3 ubiquitin ligases, and discovers a novel ligand for VHL.

10 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 19, 2023

Chemically Induced Degradation of Native Proteins by Direct Recruitment to the 26S Proteasome

Madeline Balzarini, Weijun Gui, Isuru M. Jayalath…·Thomas J. Kodadek

This study demonstrates a method to degrade native proteins by directly recruiting them to the proteasome without requiring ubiquitylation.

12 citations

proteomicsexperimental assay

𝕏 PostBluesky