Ju-Chan Park

The paper uses AI to generate a small MLH1 binder that enhances prime editing efficiency by disrupting MMR, resulting in the highest PE efficiency to date.

The paper identifies MSH2 and MSH6 as size-dependent determinants of prime editing efficiency in human embryonic stem cells, showing that their disruption significantly improves editing outcomes.

The paper establishes isogenic GNE myopathy disease models using base editors in hPSCs, showing mutation-specific hyposialylation and drug responses.

The paper develops a method to enrich genome-edited human pluripotent stem cells by inducing temporary drug resistance through SLC35F2 knockdown, achieving efficient selection in 3 weeks.