Hyeon‐Ki Jang

The paper identifies mechanisms by which CRISPR, base editors, and prime editors cause large DNA deletions and proposes strategies to mitigate them.

The paper identifies MSH2 and MSH6 as size-dependent determinants of prime editing efficiency in human embryonic stem cells, showing that their disruption significantly improves editing outcomes.

This study uses adenine base editing to correct a nonsense mutation in a mouse model of LCA, improving visual function.

The paper develops a method to enrich genome-edited human pluripotent stem cells by inducing temporary drug resistance through SLC35F2 knockdown, achieving efficient selection in 3 weeks.