Marja Jäättelä

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

This study shows that B cell-derived extracellular vesicles from activated B cells stimulate lytic gene expression of oncogenic herpesviruses.

The paper maps lipid species across human cell compartments using PAP-SL and identifies general rules of lipid organization and metabolic plasticity.

This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.

This study uses MD simulations to show that N99 glycosylation in ATG9A enhances protomer interactions and lipid scrambling, but does not significantly affect autophagy flux.

This study uses molecular dynamics simulations to investigate how acidic sphingomyelinase interacts with lysosomal membranes and how cation amphiphilic drugs like ebastine affect these interactions.

LipidDyn is a computational pipeline that analyzes MD simulations of membranes with varying compositions to extract properties like area per lipid and thickness.

This study identifies DNA-PKcs-mediated phosphorylation of AMPKγ1 as a mechanism regulating lysosomal AMPK activation by LKB1 during autophagy.