Pablo Trindade

The paper shows that SCZ astrocytes, when stimulated, induce a dystrophic phenotype in microglial-like cells through altered cytokine profiles and impaired phagocytosis.

This study uses proteomics to show LSD alters proteins involved in proteostasis, energy metabolism, and neuroplasticity in human brain organoids.

This study shows that hiPSC-derived astrocytes from schizophrenia patients have an inflammatory phenotype that reduces vascularization through secreted factors like IL-8.

This study shows that human iPSC-derived astrocytes exposed to TNF-alpha recapitulate key astrogliosis features over time, including cytokine secretion, morphological changes, and reduced aspartate uptake.