Pablo Leal Cardozo

hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cells

The paper shows that SCZ astrocytes, when stimulated, induce a dystrophic phenotype in microglial-like cells through altered cytokine profiles and impaired phagocytosis.

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease

The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.

Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human induced pluripotent stem cells-derived astrocytes

This study shows that human iPSC-derived astrocytes exposed to TNF-alpha recapitulate key astrogliosis features over time, including cytokine secretion, morphological changes, and reduced aspartate uptake.